YAKHAK HOEJI
ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
ISSN 2383-9457 (ONLINE)
Physical properties of 3D printed gastro-retentive tablet containing sarpogrelate HCl (Mean±SD, n=3)
| Run # | Thickness (mm) | Diameter (mm) | Weight variation (mg) | Friability (%) | Drug content (%) | Swelling ratio (%) | TFT (h) |
|---|---|---|---|---|---|---|---|
| F1 | 11.57±0.06 | 11.94±0.13 | 514.39±23.81 | 0.23±0.01 | 108.54±0.59 | 135.89±3.11 | 11.83±0.29 |
| F2 | 11.27±0.42 | 12.00±0.04 | 497.48±69.61 | 0.48±0.05 | 100.61±0.83 | 131.67±4.75 | 11.33±0.14 |
| F3 | 11.93±0.15 | 11.97±0.05 | 537.74±34.58 | 0.37±0.15 | 106.91±0.27 | 206.25±8.88 | 10.92±0.14 |
| F4 | 11.53±0.12 | 12.00±0.02 | 566.96±68.82 | 0.34±0.10 | 100.37±0.68 | 154.82±0.00 | 12.17±0.14 |
| F5 | 11.53±0.06 | 11.98±0.06 | 638.88±69.69 | 0.38±0.08 | 100.04±0.35 | 100.51±0.34 | 11.67±0.14 |
| F6 | 11.53±0.12 | 11.97±0.04 | 615.84±64.86 | 0.44±0.03 | 98.90±0.25 | 100.94±5.76 | 12.50±0.00 |
| F7 | 11.67±0.38 | 11.98±0.05 | 635.64±73.68 | 0.31±0.12 | 97.25±0.23 | 166.07±7.57 | 12.17±0.14 |
| F8 | 11.47±0.06 | 11.93±0.02 | 515.58±12.22 | 0.42±0.14 | 100.03±0.32 | 122.08±12.8 | 11.92±0.14 |
| F9 | 11.67±0.38 | 12.02±0.06 | 502.35±49.49 | 0.29±0.10 | 98.03±0.68 | 85.3±19.04 | 12.08±0.14 |
| F10 | 11.47±0.06 | 12.00±0.01 | 492.59±30.30 | 0.47±0.09 | 99.80±0.46 | 146.37±0.00 | 11.67±0.38 |
| F11 | 11.53±0.15 | 12.07±0.13 | 745.45±97.92 | 0.34±0.05 | 100.13±0.67 | 162.89±0.69 | 11.17±0.14 |
| F12 | 11.50±0.00 | 11.98±0.09 | 485.66±23.44 | 0.37±0.11 | 100.69±0.03 | 229.02±6.04 | 12.42±0.52 |
| F13 | 11.67±0.38 | 11.93±0.03 | 588.61±71.02 | 0.40±0.15 | 99.89±0.15 | 175.18±9.93 | 11.42±0.38 |
| F14 | 11.80±0.36 | 12.00±0.09 | 682.60±57.38 | 0.25±0.11 | 99.41±0.57 | 121.66±2.67 | 12.00±0.00 |
| F15 |
11.54±0.08 | 12.03±0.05 | 526.04±48.00 | 0.40±0.10 | 100.58±1.50 | 155.81±2.74 | 11.32±0.15 |
All formulation contained 60% of sarpogrelate HCl, TFT: Total floating time
*mean value expressed by 6 times of measure