약학회지
YAKHAK HOEJI
ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 3.

Table. 3.

Regression coefficient (R2) values of sarpogrealate HCl release data obtained from 3D printed gastro-retentive tablet

Run # Correlation coefficient (R2)
Zero order Higuchi model Hixon-Crowell First order Korsmeyer-Peppas model
k n R2 Mechanism of release T20% (min) T40% (min) T60% (min)
F1 0.8613 0.9566 0.9660 0.9901 0.00216 0.9263 0.9347 Super case II transport 132.75 280.56 434.64
F2 0.8410 0.9424 0.9808 0.9816 0.00145 1.0079 0.9879 Super case II transport 132.76 263.97 394.71
F3 0.6401 0.8235 0.8570 0.7590 0.01243 0.7367 0.8554 non-Fickian release 43.43 111.28 192.95
F4 0.9395 0.9727 0.9909 0.9981 0.00210 0.8712 0.9256 non-Fickian release 186.79 413.90 659.21
F5 0.7558 0.9333 0.9090 0.9709 0.00315 0.8946 0.9646 non-Fickian release 117.28 259.88 413.90
F6 0.7739 0.9248 0.9367 0.9632 0.00131 1.0746 0.9239 Super case II transport 107.68 205.25 299.34
F7 0.8405 0.9673 0.9582 0.9912 0.00417 0.8358 0.9972 non-Fickian release 102.59 235.12 381.92
F8 0.9776 0.9780 0.9945 0.9710 0.00383 0.7540 0.9970 non-Fickian release 189.80 475.92 814.85
F9 0.9665 0.9622 0.9937 0.9612 0.00112 0.9676 0.9929 Super case II transport 212.43 434.83 661.17
F10 0.9394 0.9870 0.9956 0.9716 0.00995 0.6424 0.9831 non-Fickian release 106.82 314.24 590.70
F11 0.9750 0.9625 0.9934 0.9631 0.00117 0.9528 0.9821 Super case II transport 220.52 456.45 698.57
F12 0.8690 0.9341 0.8917 0.8916 0.00373 0.7821 0.9895 non-Fickian release 162.69 394.48 662.49
F13 0.8315 0.9600 0.9518 0.9895 0.00572 0.7871 0.9262 non-Fickian release 91.45 228.35 383.49
F14 0.8042 0.9224 0.9424 0.9820 0.00049 1.2080 0.9988 Super case II transport 144.97 257.33 359.96
F15* 0.8292 0.9343 0.9317 0.9657 0.00056 1.1738 0.9615 Super case II transport 149.57 269.97 381.35

*mean value expressed by 6 times of measurement

Tx% is X% release (Tx%) from 3D printed tablet containing sarpogrealate HCl
Yakhak Hoeji 2022;66:76-89 https://doi.org/10.17480/psk.2022.66.2.76
© 2022 Yakhak Hoeji