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Antimicrobial Activity of Natural Quercetin Alone and in Combination with Some Antibiotics
YAKHAK HOEJI 1996;40(6):653-658
Published online December 31, 1996
© 1996 The Pharmaceutical Society of Korea.

어성국(Seong Kug Eo);김영소(Young So Kim);이종길(Chong Kil Lee);이도익(Do Ik Lee);김일혁(Il Hyuk Kim);한성순(Seong Sun Han)
As part of our search for less toxic antimicrobial agents from natural resources. rutin was isolated from Sophora japonica and then hydrolyzed to quercetin. Antimicrobial activity of quercetin was tested in vitro against five kinds of gram positive and ten kinds of gram negative bacteria by serial broth dilution method. Among fifteen kinds of bacteria tested, the antimicrobial activity of quercetin was the most potent against Proteus vulgaris showing minimal inhibitory concentration(MIC) of 125mcg/ml. To investigate the effect of antimicrobial combinations of quercetin with four kinds of antibiotics (ampicillin, cefazolin, oxytetracycline and chloramphenicol). the fractional inhibitory concentration index (FICI) was determined by checkerboard assay for each strain. The antimicrobial combinations of quercetin with four kinds of antibiotics resulted in synergism in one instance, additive effect in four instances, but no antagonism was observed.
Keywords : quercetin;antimicrobial activity;serial broth dilution method;minimal inhibitory concentration(MIC);antimicrobial combinations;fractional inhibitory concentration index(FICI).

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