Pharmacological action of Linalool, Oleanolic acid and β-caryophyllene on Gene Expression and Production of Mucin from Goblet cells in Respiratory Epithelium
Hyun Jae Lee*
Department of Health Management and Smith Liberal Arts College, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 01795, Korea
Correspondence to: Hyun Jae Lee
Department of Health Management and Smith Liberal Arts College, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 01795, Korea
Tel.: 02-3399-1909 Fax.: 02-3399-1821 E-mail: hjy1213@syu.ac.kr
Department of Health Management and Smith Liberal Arts College, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 01795, Korea
Tel.: 02-3399-1909 Fax.: 02-3399-1821 E-mail: hjy1213@syu.ac.kr
Received December 13, 2016; Revised March 16, 2017; Accepted April 3, 2017.
- Abstract
- We examined whether linalool and other natural products affect airway MUC5AC mucin gene expression and production induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with PMA for 24h. Linalool, β-caryophyllene and oleanolic acid inhibited the gene expression and production of MUC5AC mucin. This result suggests that these three compounds can inhibit the production and gene expression of mucin, through directly acting on airway epithelial cells.
- Keywords : Airway, mucin, linalool
- April 2022, 66 (2)
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